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Necrotizing sialometaplasia (NS) is a benign, ulcerative lesion, usually located towards the back of the hard palate. It is thought to be caused by ischemic necrosis (death of tissue due to lack of blood supply) of minor salivary glands in response to trauma. Often painless, the condition is self-limiting and should heal in 6–10 weeks. Although entirely benign and requiring no treatment, due to its similar appearance to oral cancer, it is sometimes misdiagnosed as malignant. Therefore, it is considered an important condition, despite its rarity. ==Signs and symptoms== The condition most commonly is located at the junction of the hard and soft palate. However, the condition may arise anywhere minor salivary glands are located.〔Minor salivary glands are found in most mucosal surfaces in the mouth, apart from the front third of the hard palate, the front third of the dorsal surface of the tongue, and the attached gingiva.(see Hupp ''et al.'' 2013, p.395)〕 It has also been occasionally reported to involve the major salivary glands.〔 It may be present only on one side, or both sides.〔 The lesion typically is 1-4 cm in diameter.〔 Initially, the lesion is a tender, erythematous (red) swelling. Later, in the ulcerated stage, the overlying mucosa breaks down to leave a deep, well-circumscribed ulcer which is yellow-gray in color and has a lobular base.〔 There is usually only minor pain,〔 and the condition is often entirely painless. There may be prodromal symptoms similar to flu before the appearance of the lesion.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Necrotizing sialometaplasia」の詳細全文を読む スポンサード リンク
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